This novel poses the question--what happens when the grim reaper decides there will be no more death? On the first day of the new year, no one dies. This of course causes consternation among politicians, religious leaders, morticians, and doctors. Among the general public, on the other hand, there is initially celebration.

Carlos is the talented heir to a notable family in fin-de-siecle Lisbon. He aspires to serve his fellow man in his chosen profession of medicine, in the arts and in politics. But he enters a society affected by powerful international influences that trouble and frustrate him and in the end he is reduced to a kind of spiritual helplessness.

Born in Paris, Jacinto is the heir to a vast estate in Portugal which he has never visited. He mixes with the creme de la creme of Paris society, but is monumentally bored. And then he receives a letter from his estate manager saying that they plan to move the bones of his ancestors to the newly renovated chapel.

A driver waiting at the traffic lights goes blind. An ophthalmologist tries to diagnose his distinctive white blindness, but is affected before he can read the textbooks. It becomes a contagion, spreading throughout the city.

In early eighteenth-century Lisbon, Baltasar, a soldier who has lost his left hand in battle, falls in love with Blimunda, a young girl with visionary powers. From the day that he follows her home from the auto-da-fe where women are burned at the stake, the two are bound body and soul by love of an unassailable strength.